As generative AI makes the mass production of technically reasonable work effortless, traditional publication metrics will face (and probably already) are facing a massive inflation. For applied ...

Nature Communications, Published online: 13 June 2026; doi:10.1038/s41467-026-74061-5 Inhibition of PLK4 is synthetic lethal in cancers with chromosome 17q TRIM37 copy number gain. Here, the authors show that while RP-1664 (PLK4 inhibitor) causes centrosome depletion in a TRIM37-dependent manner as high doses, low dose causes cell death in a TRIM37-independent manner via centrosome amplification …

Psychology offers both descriptive and analytical accounts of human experience and behavior. Science champions the latter.

Self-worth isn’t just built from within. Kind acts, empathy, and generosity can boost well-being and help us feel more connected, valued, and grounded in our shared humanity.

In 1980, Intel released the Intel 8087 floating-point coprocessor, a chip that could make math up to 100 times faster. As well as arithmetic and square roots, the 8087 computed transcendental functions including tangent, exponentiation, and logarithms. But it all depended on a 69-bit adder: "The arithmetic heart of the floating-point execution unit is centered about a nanomachine comprised of the…

There are three ways to do AI coding at home without spending like a company, and which one fits depends mostly on how much you trust the next year of hardware and model releases. The first is to self host. You buy the machine, run open source models locally, and pay nothing per token after that. The upfront cost is steep and the models you can actually run at home are weaker than what the fronti…

AI agents have fundamentally changed the complexity of inference workloads. Until now, the industry has struggled to define a standard for measuring how...

Hey, I've been working on this for a while now and finally feel okay sharing some code examples. Zen is a statically typed language that compiles to native binaries through LLVM. Still a work in progress but the core stuff works. One thing I'm kind of proud of is reactive variables. It's a first class feature where a variable automatically recomputes when something it depends on changes: int cart…

In this post, we'll build a practical AI-powered meal planning agent using HazelJS. This agent helps users create personalized meal plans, discover recipes, and generate shopping lists—all while demonstrating HazelJS's powerful agent orchestration, RAG capabilities, and production-ready patterns. What We're Building Our meal planning agent handles the complete meal planning workflow: Dietary Inta…

Students notice that their teachers are kind. Surprisingly, it's not about field trips, treats, and special activities.

The SEC EDGAR API is one of the best-kept secrets in financial data engineering: every mandatory disclosure filed by every U.S. public company, available as clean JSON, for free, with no API key. If you've ever paid for a "fundamentals" data vendor or scraped a brokerage page for a balance sheet, you've been working harder than you need to. The raw, authoritative source — quarterly revenue, insid…

Building a Global Career Opportunity Simulator Using World Bank and ESCO Data Over the past few years, I have noticed that many discussions about career opportunities focus on a single number: salary. When people evaluate opportunities in different countries, the conversation often starts and ends with compensation. While salary is important, it rarely tells the full story. Economic conditions, l…

If you come from Web2, you probably think of a token as a number in a database that moves around when people transact. On Solana, the original SPL Token program is exactly that. Token-2022 is the upgrade — and it lets you bolt behaviors directly onto the mint itself, the way you would add middleware to a payment pipeline, except the middleware lives inside the asset and cannot be bypassed. This w…

Nature Communications, Published online: 13 June 2026; doi:10.1038/s41467-026-74318-z Mechanisms underlying effective immune escape in HPV-associated oropharyngeal cancers despite the presence of immune cells are incompletely understood. Here, authors use single-cell spatial analysis to show that tumors form distinct local immune niches, including hypoxic regions and chemokine foci, that shape im…

Nature Communications, Published online: 13 June 2026; doi:10.1038/s41467-026-74448-4 Here, the authors describe four distinct DNA sequence patterns in nucleosomes that shape how transcription factors interact with chromatin, revealing previously hidden DNA-encoded rules governing nucleosome positioning and gene regulation.

Your LLM has 128K tokens. Your document has 150K words. Something has to give. What do you do? A) Chunk the document into fixed-size pieces and embed each one — retrieve the top-k at query time. B) Use a sliding window — process the document in overlapping chunks, stitch the outputs together. C) Summarize each section progressively — feed the running summary forward as context. D) Truncate to the…

Managing product data across Adobe Commerce (Magento 2), Amazon, and physical POS systems is a constant, exhausting battle for omnichannel merchants. Keeping description variants, localized pricing matrices, and high-resolution digital assets aligned across isolated operational silos quickly devolves into absolute chaos. The corporate reflex to this problem is predictable: throw enterprise budget…

An AI coding agent on your laptop runs with your shell. It can rm , it can curl secrets | nc , it can write to .github/workflows . The native guardrail in Claude Code is an allowlist: you pre-grant a set of permitted tools and it auto-denies the rest. That works, but it's blunt. It decides on the tool name, not on what the call is about to do. Bash is either allowed or it isn't. I wanted the gate…

Z.ai launches GLM-5.2 with a 1-million-token context window ahead of an MIT-licensed release next week AI Judge changed title after evaluation, original title: "Zai launches GLM-5.2 with a 1M-token context window and plans an MIT-licensed open-source release" Story Overview Zai's GLM-5.2 arrives as the latest coding-focused entry in its GLM-5 line, giving subscribers immediate use of a 1M-token w…

More than 100 UK lawmakers urge government to cancel London event, warning it is linked to land ‘stolen from Palestinians’ More than 100 UK lawmakers have called for the cancellation of an Israeli real estate event scheduled to take place in London on Sunday, which had appeared to advertise the sale of land in Israeli settlements in the occupied West Bank. In a letter sent to the foreign secretar…