Autonomic dysreflexia (AD) is a potentially life-threatening complication of high-level spinal cord injury (SCI), marked by paroxysmal hypertension. Although cerebrovascular events can be triggered by severe hypertension, the direct association between AD and intracerebral hemorrhage (ICH) necessitates increased clinical awareness. We present a case of a 71-year-old male with a complete C3 SCI (A…

Recognizing traffic signs is a fundamental perception task for automated driving systems and requires high accuracy under strict latency and energy constraints. Convolutional neural networks (CNNs) achieve strong performance but can be computationally demanding for embedded platforms. Spiking convolutional neural networks (SCNNs) offer an event-driven alternative that can reduce computation throu…

ObjectiveThis study aims to quantitatively assess the efficacy of exosome therapy for epilepsy through a systematic review and meta-analysis of preclinical animal experiments. We seek to clarify its overall effects on seizure reduction, cognitive function preservation, and neuroinflammation suppression.MethodsA systematic search was conducted across four English-language and four Chinese database…

Parkinson’s disease (PD) is a major neurodegenerative disorder characterized by progressive loss of dopaminergic neurons and accumulation of α-synuclein. Current treatments primarily focus on symptom alleviation, highlighting the necessity for identifying novel molecular therapeutic targets. RNA editing, as a post-transcriptional process that modifies RNA sequences without altering genomic DNA, i…

PurposeTo investigate the short-term effect of a longpass filter on myopic defocus-induced changes in axial length (AL) and choroidal thickness (ChT).MethodsThis study included 23 young myopic adults. AL and ChT were measured in both eyes before and after 60 min of +5 D myopic defocus induced in the right eye with either a longpass filter (>495 nm) or a neutral density (ND) filter of equal transm…

The autophagy-lysosomal pathway (ALP) is a critical intracellular protein degradation system responsible for maintaining proteostasis and metabolic balance within cells. Dysfunction of this pathway has been increasingly recognized as a key pathological basis underlying various neurodegenerative diseases (NDs). This review provides a comprehensive overview of the molecular mechanisms by which ALP …

Information and energy are treated as separate concepts across different scientific disciplines. This paper presents three everyday examples — hard drives, genes, and rivers with their riverbeds — to demonstrate that information and energy are ontologically inseparable. It further argues that anything that exists simultaneously possesses informational structure (distinguishability) and energetic …

We introduce a measurement framework for analyzing how neural representations diverge under transformations of increasing complexity. Rather than proposing a universal theory of representation learning or invariance, we define a single observable, $\Delta(c)$, which measures inter-model variance in representation stability across heterogeneous neural architectures. The framework is designed as an…

Nature Medicine, Published online: 15 May 2026; doi:10.1038/s41591-026-04412-8 What Galen’s dissections reveal about tacit learning in modern medical education

Nature Medicine, Published online: 15 May 2026; doi:10.1038/s41591-026-04402-w An open-label, randomized controlled phase 2 trial comparing favipiravir with ribavirin for the treatment of mild-to-moderate Lassa fever in Nigeria found that favipiravir was safe and well tolerated and supports its further optimization as a treatment alternative.

Nature Medicine, Published online: 15 May 2026; doi:10.1038/s41591-026-04410-w Part of the Hong Kong Genome Project, genomic analyses of more than 20,000 participants provide information on clinically relevant variants for the Chinese population and offer insights on the implementation of genomic medicine initiatives.

Nature Communications, Published online: 15 May 2026; doi:10.1038/s41467-026-71348-5 NUMTs record mitochondrial‑to‑nuclear DNA transfer, but their diversity is not well defined. Here, the authors create a pangenome‑based NUMT map, revealing hundreds of fixed and polymorphic events, regulatory activity, lineage‑specific dynamics and NUMT‑derived tandem repeats.

Nature Communications, Published online: 15 May 2026; doi:10.1038/s41467-026-70868-4 Enzymatic PET depolymerization offers a sustainable method for the recycling of post-consumer PET waste, but the low stability and activity of some of PET-degrading enzymes hinders their practical application. Here, the authors engineer Polyester Hydrolase Leipzig 7 (PHL7), a PET hydrolase derived from a compost …

Nature Cell Biology, Published online: 15 May 2026; doi:10.1038/s41556-026-01940-w This Review presents the formation of large extracellular vesicle (L-EV) subsets, highlighting that their contents and physiological relevance, for example, in intercellular communication, are driven by the different mechanisms underlying their biogenesis.

At a burial depth of 5,000 m, large gas resources are hosted in Lower Triassic oolitic shoal carbonates in the Puguang Field, Sichuan, China. Dissolution and dolomitization primarily preserve effective porosity and permeability, whereas heterogeneous diagenetic fabrics strongly limit hydrocarbon production. This study characterizes spatial variations in rock texture across the Feixianguan Formati…

In order to effectively manage water quality, current surface water quality must be closely monitored and evaluated. The Water Quality Index (WQI) is currently used to evaluate surface water quality. However, the calculation of WQI is complicated and time-consuming. In order to optimize the surface water quality assessment of the study area, it is essential to conduct research to develop an effic…

Understanding the sedimentary framework and reconstructing deep-time source-to-sink (S2S) systems in rift basins are critical for predicting reservoir distribution and reducing exploration risk in structurally complex offshore settings. We present a geology-informed Bayesian deep learning framework that explicitly encodes geological priors within graph neural networks, variational autoencoders an…

Near dawn on 6 February 2023, at 4:17 a.m. local time, residents of Pazarcık City in southern Turkey experienced powerful shaking. Witnesses described their experiences of being shaken from their sleep, some running to their cars for safety from the damaged buildings. “I have never felt anything like it in the 40 years I’ve lived,” said Erdem, a witness living in Gaziantep. “We were shaken at lea…