Nature Communications, Published online: 11 June 2026; doi:10.1038/s41467-026-73980-7 Cancer associated fibroblasts (CAFs) are important regulators of breast cancer (BC) progression. Here the authors identify a distinct pro tumorigenic myofibroblastic CAF population that derives from bone-resident Osterix+ osteolineage cells and retains osteolineage features in the tumor microenviroment.

The University of California will consider bringing back SAT and ACT requirements for first-year admissions. UC ended test requirements in 2020.

npj Vaccines, Published online: 10 June 2026; doi:10.1038/s41541-026-01500-1 Evaluating large language models on multilingual vaccine knowledge: a benchmark study

Lithium-sulfur (Li-S) batteries are promising next-generation energy storage systems due to their high theoretical energy density. However, their practical implementation is hindered by the low conductivity of sulfur and the polysulfide shuttle effect. In this work, garlic-braid-derived biochar was investigated as a sustainable sulfur host for Li-S battery cathodes. Biochar obtained from garlic b…

BackgroundMajor depressive disorder (MDD) in adolescents remains a significant public health challenge. Treatment-resistant depression (TRD) affects a substantial proportion of cases and is associated with chronic symptoms, comorbidities, and elevated suicide risk. Standard treatments frequently show limited success, leading to off-label consideration of atypical antipsychotics as augmentation ag…

Adolescents who spend at least two hours a day on social media are more likely to experience depressive symptoms and poorer wellbeing, with the strongest effects in early adolescence, according to new research.

Google has stepped into the world of 3D printing in a big way. The post Google Releases Enables 3D Printed Fitbit Air Band Designs appeared on Fabbaloo .

I have activity data from treatment and control cohorts measured in biological samples, where each sample is recorded across multiple timepoints (different days). In my current analysis, each box in ...

I posted a question yesterday and it was closed due to duplicate because some thought I was asking for a definition of canonical morphism. I would make it a more focused question: In category thory I ...

Collagen, the protein that builds skin, bones, tendons and organs, exists inside cells as a liquid-like droplet rather than the long, rigid rod seen in textbooks over the last half century, according to a new study from the Centre for Genomic Regulation (CRG) in Barcelona.

I have never been a big fan of pull requests. Before agents, it was easier to believe that the ceremony of trading comments on snapshots was an effective way to collaborate on software, but it never really worked for the Zed team. We frequently work together in the same worktree, building trust and shared understanding by discussing the code as we write it. GitHub doesn't let you talk about code …

A review article now published in "Nature Reviews Genetics" brings together evolutionary theory, comparative genomics and large-scale human genetics to explain why we age and why aging rates differ among individuals and species.

Vance Boelter changes plea in murders of Melissa and Mark Hortman as prosecutors agree not to pursue death penalty The man charged in the political assassinations of the top Democrat in the Minnesota house and her husband, as well as the nonfatal shootings of a state senator and his wife, pleaded guilty in federal court on Thursday after prosecutors said they would not seek the death penalty. Van…

I used to love coding in my free time. Back in university, it was basically my main hobby. I liked building things, breaking things, trying out random ideas, starting side projects that were probably too big, and learning new tech just because it seemed interesting. That was also the reason I wanted to become a developer in the first place. Then I actually became one. And somehow, over time, codi…

El Niño has officially arrived, and the latest edition is shaping up to be particularly potent — potentially bringing higher amounts of rain to Southern California.

Paul Brannen extols the benefits of commercial forestry, while Dr Andrew Cameron warns of Britain ‘offshoring’ its timbers supplies, and Jane Gifford calls on the Scottish government to review its forestry policy Last week you published a well-balanced piece on the success story that is Kielder Forest ( How England’s largest forest went from commodity to conservation haven, 2 June ). At the heart…

What are Dark Tetrad characteristics, and why might some people use these traits and behaviors as a strategy in their relationships?

The programme So Are We marks the first time a British company has performed the work of choreographers Sol León and Paul Lightfoot. Tristram Kenton took a first look at Covent Garden Continue reading...

The rise of AI agents has created a new challenge for developers: how can Large Language Models (LLMs) securely and consistently interact with external systems? Modern AI applications need access to tools, databases, APIs, documents, and business applications. Traditionally, every integration required custom code, making AI systems difficult to maintain and scale. This is where the Model Context …

Researchers at the University of California San Diego have completed a massive genetic study that identifies key biological drivers of cocaine addiction, uncovering a potential new target for treatment that resides in the liver rather than the brain.