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Disneyland's Big Thunder Mountain My next entry in the Geology of the Disney parks is Disneyland's Big Thunder Mountain. I am specifying that this is "Disneyland's" version of the ride because even though the ride has been replicated three other times in parks around the world (two of which also have the a centerpiece dinosaur skeleton), this one is unique to Disneyland. Here is the setup for the…

Nature Communications, Published online: 14 September 2026; doi:10.1038/s41467-026-77638-2 Treatment for frontotemporal dementia due to GRN haploinsufficiency (FTD-GRN) are lacking. Here, in this preclinical and Phase 1 clinical trial, the authors show that VES001, an oral small molecule sortilin inhibitor, is safe and well tolerated, and increased progranulin levels.

Nature Communications, Published online: 14 September 2026; doi:10.1038/s41467-026-74896-y Here, the authors show that coconut oil and the fatty acid myristic acid suppress Crohn disease-like intestinal inflammation in mice through multiple mechanisms, supporting a potential role for these dietary fats in promoting protective immune gut responses in Crohn’s disease.

Radioligand therapy (RLT) delivers therapeutic radionuclides to tumor-associated targets through specific targeting ligands and has demonstrated substantial clinical value in malignancies such as prostate cancer and neuroendocrine tumors. Beyond its direct induction of radiation-mediated tumor cell damage, RLT has attracted increasing attention for its potential immunomodulatory effects. Current …

Yasmin is an advisor in our Advanced Technologies and Fusion Strategy team. Here she highlights the benefits of our new early engagement process and the Environment Agency’s role regulating the fusion industry. The Environment Agency, working alongside the Health and Safety Executive, is the regulator of fusion research sites and will jointly regulate future commercial …

Wison Engineering Ltd. (Shanghai, China) and Axens (Rueil-Malmaison, France) signed a Memorandum of Understanding (MOU) to explore collaboration opportunities on selected e-SAF projects (sustainable aviation fuel, based on Fischer-Tropsch pathway). Through this framework, the two companies will jointly assess practical execution approaches that combine Axens’ process technology expertise and Wiso…

Consider a system of $3N$ particles with $p$ holonomic constraints: $$ g_v( \vec{r}_1 , \vec{r}_2 , ... , \vec{r}_N , t ) = 0 \, , \quad v = 1,2, ... , p \, .$$ Various textbooks state that the current spatial configuration of a system of $3N$ particles with $p$ holonomic constraints is determined by $3N-p$ independent coordinates $q_1,...,q_{3N-p}$ . Independent means that there is no relation o…

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