Nature Neuroscience, Published online: 15 May 2026; doi:10.1038/s41593-026-02269-1 Autism is remarkably heterogeneous, posing a long-standing challenge for linking genetics to brain dynamics. A cross-species study identifies two principal dysconnectivity signatures across 20 mouse models of autism risk, each associated with distinct molecular pathways, and shows analogous connectivity patterns in…

Nature Neuroscience, Published online: 15 May 2026; doi:10.1038/s41593-026-02282-4 The axon initial segment was known to receive GABAergic synaptic inputs. Yang et al. show that it can be excited directly via specialized ‘axonic spines’. These spines thus boost neuronal firing and act as a fast track to route circuit information.

Nature Neuroscience, Published online: 15 May 2026; doi:10.1038/s41593-026-02287-z Pagani et al. used cross-species fMRI to reveal two autism subtypes, characterized by lower and higher brain connectivity and linked to synaptic and immune-related pathways, respectively.

Executive Summary Over four iterations and 200+ adversarial wargame rounds, we evolved a local AI swarm's defense rate from 53% to 90% — without changing hardware, adding cloud dependencies, or increasing VRAM usage. The key innovations: a "Defender Vanguard" prompt injection technique that teaches tiny models to think like attackers, and an auto-healing system that extracts vaccines from every b…

Originally published on malcolmlow.net In quantum computing, anything that "knows" what a qubit is doing acts as a Witness . Leftover data ( Junk Bits ) on an ancilla qubit act as witnesses, destroying the interference your algorithm needs to work. 1 . The Observer Effect Consider a simple circuit where a qubit passes through two Hadamard gates. Classically, two inversions cancel. Quantum mechani…

You've heard of DevOps. You've heard of AIOps. You've probably heard of MLOps. But there's a category that doesn't exist yet — and it's the one the AI industry needs most desperately. Agent Runtime Operations. Here's why. The Gap Nobody Talks About Everyone is building agents. Anthropic's Claude Code, OpenAI's Codex, Google's Jules, Cursor, Windsurf, CrewAI, LangGraph — the list grows weekly. 86%…

Originally published on malcolmlow.net Grover's algorithm is a quantum search procedure that locates a marked item in an unsorted list of N items in O(√N) oracle queries — a quadratic speedup over any classical approach. For N = 8 (3 qubits), this means roughly ⌊π/4 × √8⌋ = 2 optimal iterations before the probability of measuring the target state peaks. This walkthrough tracks the exact amplitude…

Originally published on malcolmlow.net In the Grover's Algorithm — Inversion About the Mean walkthrough, the diffusion operator applies H⊗³ twice per iteration. Every single step is governed by a sign table called the Hadamard Reference . That table is not a lookup shortcut — it is the 8×8 Walsh-Hadamard Transform matrix written out in full. This post derives it from scratch: one qubit, then two,…

The day before the annual Long Beach Pride Festival was set to kick off, the city announced that the event had instead been canceled — pointing blame at the organizer for failing to provide required safety information in time.

I am attempting to homebrew a race that has 8 eyes like a spider. The eyes are spread around the head in a circle. I was wondering if this would innately give them darkvision. Otherwise, the race ...

Intro I've been using AI tools such as Claude Code , Codex , and others when coding at work for more than a year. They surely speed up my coding. However, I am still writing documentations in Microsoft Word (Word) manually. So this time, I tried exploring how we can write documentations automatically using AI. Writing without Word is easier, but for now, our customers require Word, so I'll write …

Originally published at recca0120.github.io You have access to a GitHub repo, but the SSH key isn't the default ~/.ssh/id_rsa or ~/.ssh/id_ed25519 . Running git clone directly gives you Repository not found . This post covers three ways to specify which SSH key to use, including the common pitfall with ~/.ssh/config Host aliases. The Problem I needed to clone a private repo: git clone git@github.…

The array is the most fundamental data structure in programming. Almost every complex structure — stacks, queues, heaps — is built on top of arrays internally. 📦 What is an Array? An array stores elements in continuous memory locations , each accessible by an index starting at 0. const fruits = [ ' Apple ' , ' Banana ' , ' Eggs ' , ' Juice ' ]; // fruits[0] = 'Apple', fruits[2] = 'Eggs' If you wa…

We introduce a unified formal framework for analysing what we term AI-mediated cognitive decoupling: the systematic separation of cognitive process from cognitive product enabled by large language models (LLMs) operating as expansion and compression agents. We formalise two operators — the expansion operator E and the compression operator C — acting on semantic content, and characterise the compo…

The core dilemma of modern physics stems from two unproven ontological presuppositions: that spacetime is an innate container preceding matter, and that matter is an entity composed of indivisible particles. These presuppositions have led to the fundamental split between general relativity and quantum mechanics, giving rise to a series of century-old unsolved problems such as wave-particle dualit…

_Enterprise Compliance Evidence Systems_. 2026Enterprise compliance documentation is often written after systems have already changed, which leaves policy narratives, architecture diagrams, runbooks, and audit evidence out of sync with executable behavior. This paper proposes Retrieval-Grounded Documentation Agents (RGDA), a synthetic architecture in which bounded documentation agents maintain co…

We develop a quantitative information-theoretic account of semantic decay in large- language-model (LLM) mediated ExpansionCompression (EC) loops. Building on the unied framework of DECO Paper 0 (Han, 2026a), we introduce semantic en- tropy HS(X) as the dierential entropy of a random variable distributed over a semantic manifold, and prove that each application of the EC-transform T = C ◦ E is a …

We model the Expansion–Compression (EC) loop introduced in the DECO series as a discrete-time closed-loop control system, with the LLM expansion operator E as a forward gain element and the LLM compression operator C as a feedback element. Using the transfer-function formalism of linear systems theory and its nonlinear extensions, we analyse the stability, convergence properties, and phase transi…